Breast Cancer Breakthroughs Episode 19: Highlights from SABCS 2025

The San Antonio Breast Cancer Symposium (SABCS) is the largest annual gathering of breast cancer clinicians, patients, advocates and researchers in the world. In this episode of Breast Cancer Breakthroughs, we’ll hear from Komen Scientific Advisory Board member Ben Ho Park, M.D., Ph.D., Komen Scholar, Reshma Jagsi, M.D., D.Phil., and Komen Scholar Susan Domchek, M.D., along with Komen Advocate in Science Jane Perlmutter, Ph.D., M.B.A., as they discuss some of what was presented at SABCS and why it matters for individuals with breast cancer.

Speakers:
- Kelsey Hampton, PhD, is Director, Mission Communications & Education at Susan G. Komen
- Ben Ho Park, M.D., Ph.D., Professor of Medicine, Vanderbilt University Medical Center
- Reshma Jagsi, M.D., D.Phil., Professor and Chair, Emory University
- Susan Domchek, M.D., Professor of Oncology, University of Pennsylvania
- Jane Perlmutter, Ph.D., M.B.A., Komen Advocate in Science

Primary Links:
- Sign up for reminders about future episodes of Breast Cancer Breakthroughs here: https://www.komen.org/about-komen/our-impact/breast-cancer/breast-cancer-breakthroughs-series/
- Link to Survey: https://susangkomen.iad1.qualtrics.com/jfe/form/SV_b4pVz10XB2gPJoq
- Clinical Trial Finder: https://www.breastcancertrials.org/BCTIncludes/index.html

Videos:
- Breast Cancer Breakthroughs Ep. 2 – Demystifying Treatment De-escalation: https://www.youtube.com/watch?v=GhyArh6nBFM
- Breast Cancer Breakthroughs - A Window into Breast Cancer through a Blood Test: https://www.youtube.com/watch?v=GUdRsV_gdwM

Additional Resources:
- Blog - Honoring Excellence in Breast Cancer Research, Treatment and Advocacy – Meet the 2025 Susan G. Komen Award Recipients: https://www.komen.org/blog/2025-susan-g-komen-award-recipients/
- Blog - Susan G. Komen-Led Research Spotlighted at SABCS 2025: https://www.komen.org/blog/komen-led-research-sabcs-2025/
- Blog - What We’re Watching at SABCS 2025: https://www.komen.org/blog/sabcs-watch-2025/
- Blog - Shining a Spotlight on Patient Advocate Involvement at SABCS: https://www.komen.org/blog/shining-a-spotlight-on-patient-advocate-involvement-at-sabcs/
- Emerging Areas in Metastatic Breast Cancer (ctDNA): https://www.komen.org/breast-cancer/metastatic/emerging-areas/#ctdna
- Emerging Areas in Early Breast Cancer (ctDNA): https://www.komen.org/breast-cancer/treatment/emerging-areas/drug-therapies/#ctdna
- Get Involved with Komen’s Mission: https://www.komen.org/get-involved/

Clinical Trials Mentioned in Episode:
- INSEMA Clinical Trial: https://clinicaltrials.gov/study/NCT02466737
- HER2CLIMB-05 Clinical Trial: https://clinicaltrials.gov/study/NCT05132582
- LidERA Clinical Trial: https://clinicaltrials.gov/study/NCT04961996
- TAILORx Clinical Trial: https://clinicaltrials.gov/study/NCT00310180
- WISDOM Clinical Trial: https://clinicaltrials.gov/study/NCT02620852

00:00 Introduction
01:15 Treatment De-escalation in the Axilla and the INSEMA Trial
04:46 Patient Voice at SABCS
07:00 Liquid Biopsy and ctDNA
09:50 HER2CLIMB-05 Trial
11:25 LidERA Trial
12:17 TAILORx AI Analysis
13:10 WISDOM Trial
14:48 Conclusion