CHIP-BCIS3: Left ventricular unloading in high-risk PCI

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Aaysha Cader interviews Divaka Perera regarding the CHIP-BCIS3 randomized trial, which evaluated whether elective left ventricular (LV) unloading during high-risk PCI improves outcomes in patients with severe LV dysfunction, extensive coronary disease, and complex procedures.
The results of CHIP-BCIS 3 showed that in elective high-risk PCI, an LV unloading strategy with a microaxial flow pump did not reduce MACE compared to standard of care. Overall, the study concludes that routine elective LV unloading in this population does not improve outcomes and may be harmful, highlighting the importance of procedural strategy (e.g., staged PCI) over systematic device use.

More updates on a selection of major LBTs of interest in interventional cardiology presented at the American College of Cardiology 2026 Scientific Sessions #ACC26 :
https://www.pcronline.com/News/Congress-coverages/ACC/2026/PCR-ACC-Scientific-Sessions
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Cardiology
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