Did One Tiny Tweak Just Solve Heart Disease?

???? Get your personalized health plan: https://drstanfield.com

✔️ X: https://x.com/BradStanfieldMD
✔️ Patreon: https://www.patreon.com/bradstanfieldmd

Here are the links to the research papers referenced in the video:
Verve-102 adverse events
https://www.cgtlive.com/view/verve-moves-on-second-gen-cardiovascular-crispr-therapy-verve-102-adverse-events

Framingham Heart Study — about
https://www.framinghamheartstudy.org/fhs-about/

Optimal LDL 50–70 mg/dL
https://pubmed.ncbi.nlm.nih.gov/15172426/

LDL causes ASCVD (EAS consensus)
https://academic.oup.com/eurheartj/article/38/32/2459/3745109

Broken PCSK9 protects against CHD
https://www.nejm.org/doi/full/10.1056/NEJMoa054013

Lower LDL extends lifespan (MR)
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14811

CRISPR-Cas9 discovery history
https://pmc.ncbi.nlm.nih.gov/articles/PMC9377665/

CRISPR acquired resistance (2007)
https://embryo.asu.edu/pages/crispr-acquired-resistance-against-viruses-2007

CRISPR is bacterial immunity
https://www.science.org/doi/10.1126/science.1138140

Programmable Cas9 DNA cleavage
https://www.science.org/doi/10.1126/science.1225829

2020 Nobel Chemistry for CRISPR
https://pmc.ncbi.nlm.nih.gov/articles/PMC7782372/

CRISPR causes large deletions
https://pmc.ncbi.nlm.nih.gov/articles/PMC6390938/

SCID-X1 gene therapy leukemia
https://www.jci.org/articles/view/35700

David Liu — Broad bio
https://www.broadinstitute.org/bios/david-liu

David Liu profile — Harvard Magazine
https://www.harvardmagazine.com/science/david-liu-harvard-gene-editing-research-disease-cures

VERVE-102 Heart-2 trial (NEJM)
https://www.nejm.org/doi/full/10.1056/NEJMoa2601283

Intellia MAGNITUDE clinical hold
https://ir.intelliatx.com/news-releases/news-release-details/intellia-therapeutics-provides-update-magnitude-clinical-trials

Intellia nex-z patient death
https://www.cgtlive.com/view/patient-treated-trial-intellia-transthyretin-amyloidosis-gene-editing-therapy-nex-z-dies

Liu Breakthrough Prize / Tapley — Harvard Gazette
https://news.harvard.edu/gazette/story/2025/04/rewriting-genetic-destiny-gene-base-editing/

Base-edited CAR7 T-cells in T-ALL (NEJM)
https://www.nejm.org/doi/full/10.1056/NEJMoa2505478

PCSK9 base editing in primates (Nature)
https://www.nature.com/articles/s41586-021-03534-y

Lilly VERVE-102 results
https://investor.lilly.com/news-releases/news-release-details/single-dose-lillys-pcsk9-base-editor-verve-102-reduced-pcsk9-88

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.