Digoxin (Digitalis) Mechanism of Action | Heart Failure Pharmacology

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Published Apr 18, 2025

Heart Failure Drugs Explained: MOA of Key Classes | MedLive Pharmacology | Dr Priyanka

Navigating the complex world of Heart Failure medications? ???? Let's simplify it! Understand the Mechanism of Action (MOA) of the major drug classes used to treat Heart Failure.
Join Dr. Priyanka Sachdev for a comprehensive overview essential for MBBS students (reflecting current understanding in 2025):
✅ Quick recap: Goals of HF therapy (reduce mortality, morbidity, symptoms).
✅ RAAS Inhibitors: How ACEi (-prils), ARBs (-sartans), and ARNIs (Sacubitril/Valsartan) combat neurohormonal activation. MOA focus!
✅ Beta-Blockers: Why specific agents (Metoprolol Succinate, Carvedilol, Bisoprolol) are crucial & their MOA in blocking sympathetic overactivity.
✅ Diuretics:
Loop Diuretics (e.g., Furosemide): MOA for rapid symptom relief (preload reduction).
Aldosterone Antagonists (Spironolactone/Eplerenone): MOA beyond diuresis (anti-fibrotic, anti-remodeling effects).

✅ SGLT2 Inhibitors (-gliflozins): The newer players! Understanding their MOA in Heart Failure (it's more than just glucose!).
✅ Vasodilators (Hydralazine/Nitrates): MOA in reducing preload and afterload.

✅ Positive Inotropes (like Digoxin): Quick MOA recap (or link to dedicated video).
✅ Understanding why each class helps manage Heart Failure symptoms and progression.
This rapid revision is just a small glimpse into the comprehensive "Prof Buster Live" course, available exclusively on the MedLive by Dr. Priyanka App!

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