Electrical Network Discovered in Aggressive Lung Cancer

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Researchers have found that some aggressive lung cancer cells can develop their own electric network, just like the one seen in the body’s nervous system.

Using neuroscience techniques, they found that the small cell lung cancer (SCLC) cells were able to go ‘off grid’. The cells were able to generate their own electrical activity, building an electrical network within the tumour, and becoming independent of the body’s main electrical supply.

Visit our website to find out more about the study: https://www.crick.ac.uk/news/2025-02-12_lung-cancer-cells-can-go-off-grid

*Useful terms*
• Metastases or 'secondary cancers' are cancerous cells that have broken away from where the • cancer first started and settled and grown somewhere else in the body.
• Neurons or nerve cells are specialised cells that make up our brain and spinal cord and control everything we do.
• Neuroendocrine cells are similar to neurons, but they also produce hormones.
• Tetrodotoxin is a poisonous compound found in the ovaries of some pufferfishes.

#oncology #smallcell #lungcancer

*In this video:*
00:00 Intro
00:35 Small Cell Lung Cancer
01:11 Two Main Cell Types
01:38 What is a Neuron?
02:03 Hypothesis
02:23 Finding 1: SCLC Tumours Show Electrical Activity
02:54 Finding 2: More Electrically Active = More Aggressive Tumours
03:45 Finding 3: SCLC Surrounded by Lung Nerves in Early Development
04:13 Finding 4: Relationship between the two cell types
04:47 Conclusion

*The Francis Crick Institute*
The Francis Crick Institute is a biomedical research institute and independent charity. We bring together people from different fields and specialisms to tackle some of the biggest questions in health and disease. Based in the heart of London’s Kings Cross, we’re home to more than 2,000 scientists and a free public exhibition space.

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Category
Oncology
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