Lung cancer highlights from ASCO 2025

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João Alessi, MD, Dana-Farber Cancer Institute, Boston, MA, and Alessandro Di Federico, MD, Dana-Farber Cancer Institute, Boston, MA, discuss key findings in lung cancer management from ASCO 2025. They highlight the practice-changing results of the DeLLphi-304 trial (NCT05740566) showing tarlatamab's impressive efficacy in second-line small cell lung cancer, with over 13 months median overall survival, and discuss promising results from the OptiTROP-Lung03 trial (NCT05631262) testing sacituzumab tirumotecan for EGFR-mutant non-small cell lung cancer patients. The conversation also covers updated results from the CheckMate 816 trial (NCT02998528) on neoadjuvant chemo-immunotherapy and the surprising success of the ALNEO trial in ALK-rearranged resectable stage III non-small cell lung cancer. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Oncology
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