Major Update on KETO-CTA

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In this video, we share a critical update on the controversial KETO-CTA study, which followed 100 participants with high-resolution coronary CT angiograms taken one year apart. While our original published analysis from Cleerly reported near-universal plaque progression, newly available data—including a fully blinded independent analysis from Heartflow and additional QAngio results—tell a more nuanced story. These independent platforms produced findings consistent with each other, yet substantially different from the original Cleerly study results.
 
We also review a major new development: individual scan submissions from study participants that were analyzed separately through Cleerly in a blinded fashion. Among the eight participants with both baseline and follow-up submissions, results differed markedly from the original study dataset, with half of cases reversing direction from progression to regression. We place these findings in context, outline steps being taken with the journal regarding the prior publication, and share details about our updated preprint and ongoing transparency efforts.

The Impact of Sustained LDL-C Elevation on Plaque Changes: Primary Coronary plaque progression results from the Keto CTA Study (Preprint of QAngio and Heartflow analyses) https://www.medrxiv.org/content/10.64898/2026.01.15.26343955v1

https://CitizenScienceFoundation.org
 
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Cardiology
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