Part 2: Renal Denervation in Resistant Hypertension | Dr. V. Rajasekhar | ACCC’25 Day 1

In this session, Dr. V. Rajasekhar, Sr. Consultant, Interventional Cardiologist & Electrophysiologist, Yashoda Hospitals, Hitec City, Hyderabad explores the clinical science and therapeutic potential of renal denervation (RDN) for patients with resistant hypertension. He explains how radiofrequency-based systems like the Symplicity Spyral catheter disrupt the afferent and efferent renal nerves, helping reduce sympathetic drive and achieve sustained blood pressure control.

Drawing on global evidence from SPYRAL HTN-OFF, SPYRAL HTN-ON, and real-world registry data, Dr. Rajasekhar highlights how RDN delivers immediate and long-term reductions in both systolic and diastolic BP, across medication and gender groups. He also reviews safety outcomes, showing RDN is well-tolerated with minimal vascular complications.

The talk emphasizes shared decision-making between patient and physician and positions RDN as an adjunct that may reduce pill burden rather than replace medications entirely. Dr. Rajasekhar also touches upon emerging ultrasound-based RDN systems, like the Paradise system, as promising alternatives under evaluation.

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