QT Prolongation in Oncology: Mastering Cardio Toxicities for Cancer Patients

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Published Nov 8, 2025

QT prolongation oncology cardiovascular toxicities cancer patients GCOS 2025 practical playbook risk benefit balance.
Dive into the essentials of QT prolongation from the GCOS 2025 session 'Morning with the Masters' led by Chris Plummer. Learn what the QT interval represents, its clinical importance, accurate measurement techniques, heart rate corrections, and management strategies for prolonged QT or torsades de pointes in oncology.
Key topics covered:
- Basics of ventricular depolarization and repolarization on ECG.
- Risks and real-world examples of QT prolongation in cancer therapy.
- Accurate QTc measurement using manual methods, handling U waves, and preferring Fridericia over Bazett correction.
- Rethinking normal ranges and when to monitor QT intervals.
- Identifying high-risk drugs and adopting a competing-risks framework.
- Practical steps for managing QT prolongation during treatment, including thresholds and resuming therapy.
- Handling torsades de pointes with emergency protocols like magnesium and pacing.
- Future opportunities with AI and data for precision cardio-oncology.
This video provides a pragmatic approach to balance oncologic benefits with cardiac safety, reducing harm while preserving cancer care intent.