Rare Brain Metastasis in Prostate Cancer Despite Undetectable PSA – Dr. Luciano Stumbo

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Published Apr 15, 2025

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Oncology Bytes – IUCS 2024

In this episode of Oncology Bytes, we speak with Dr. Luciano Stumbo, an oncologist at University Hospital Campus Bio-Medico in Rome, about a striking and rare case presented at the International Urology Cancer Summit (IUCS 2024).

Dr. Stumbo discusses a patient with hormone-sensitive metastatic prostate cancer who developed multiple brain metastases while on apalutamide therapy, despite having persistently undetectable PSA levels.
???? This case challenges the clinical reliance on PSA as a disease activity marker and brings attention to:
The rare incidence of brain metastases in prostate cancer (~1–2%)
The limited CNS penetration of second-generation AR inhibitors like apalutamide

Why MRI brain imaging may be warranted in young, high-risk prostate cancer patients

???? Read the full abstract: https://bit.ly/AbstractDrLuciano

???? A must-watch for oncologists and urology professionals managing advanced prostate cancer cases.
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