2025 Breast Cancer Immunotherapy Trials: Key Updates from Dr. LeVee | MOASC/ANCO

ARTICLE: https://oncologytube.com/breast-cancer-immunotherapy-trials-2025/
Join Dr. Alexis LeVee, MD, Clinical Instructor of Medicine at UCLA David Geffen School of Medicine, as she presents groundbreaking 2025 updates on breast cancer immunotherapy trials at the MOASC/ANCO Immuno-Oncology Symposium: Emerging Data & Evolving Paradigms (September 6, 2025). From de-escalating neoadjuvant therapy in early TNBC to novel combinations in metastatic settings, discover how trials like KEYNOTE-522, neoPACT, NeoSTAR, BELLINI, and ASCENT-04 are reshaping treatment paradigms for oncologists and patients.

Highlights include:

Chemo-sparing strategies with dual ICIs achieving up to 47% pCR in high-TIL TNBC (BELLINI trial).
Anthracycline-free regimens hitting 58% pCR (neoPACT).
SG + pembrolizumab boosting PFS to 11.2 months in advanced TNBC (ASCENT-04).

Ideal for oncology professionals seeking actionable insights on biomarkers, ADCs, and emerging compounds. Full slides and resources available at moasc.org and anco.org.

Timestamps:
0:00 - Opening Teaser: BELLINI & ASCENT-04 Highlights
0:30 - Dr. LeVee's MOASC Young Investigator Award & Gut Microbiome Project
1:15 - KEYNOTE-522: Pembrolizumab Approval in Early TNBC
2:30 - neoPACT Trial: Anthracycline-Free Regimen (58% pCR)
3:45 - NeoSTAR Trial: SG + Pembrolizumab (33-50% pCR)
5:00 - BELLINI Trial: Dual ICI Without Chemo (33-47% pCR)
6:15 - Adjuvant De-Escalation: OptimICE-pCR & OPT-PEMBRO
7:30 - Adjuvant Escalation for Residual Disease: ASCENT-05, TROPION-Breast03
8:45 - Metastatic TNBC: ASCENT-04 Results (11.2 mo PFS)
10:00 - Novel Strategies: Ivonescimab, Bispecifics, & Cellular Therapies
11:15 - Biomarkers: TILs, MammaPrint, & ImPrint Signatures
12:30 - Q&A & Closing: Future Directions
Subscribe for more oncology updates from leading experts! #BreastCancerTrials #Immunotherapy
Presented by UCLA Health | Jonsson Comprehensive Cancer Center. (Recorded September 6, 2025)

Video interviews to be posted from this event at these websites...
https://oncologytube.com/tag/moasc/
https://moasc.org/
https://anco.org/

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