ESC Highlights, Reporting Guidelines for Target Trial Emulation Studies, LSD for Anxiety and more

Editor’s Summary by Linda Brubaker, MD, and Preeti Malani, MD, MSJ, Deputy Editors of JAMA, the Journal of the American Medical Association, for articles published from August 30-September 5, 2025.

00:00 Intro

Research
05:50 JAMA at ESC
01:29 Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults
02:02 RSV Vaccine Effectiveness Against Hospitalization Among US Adults Aged 60 Years or Older During 2 Seasons
02:51 Related Editorial: Shot Through the Heart—Can RSV Vaccination Reduce Risk of Cardiovascular Outcomes?
03:12 Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction
04:46 Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation
05:25 Related Editorial: Lifelong Anticoagulation After AF Ablation—Time to Reconsider?
05:58 Fractional Flow Reserve–Guided Complete vs Culprit-Only Revascularization in Non–ST-Elevation Myocardial Infarction and Multivessel Disease
06:13 Helicobacter pylori Screening After Acute Myocardial Infarction
06:36 Reporting of Clinical Trial Uncertainties With New Cancer Drugs in Journal Publications and Clinical Guidelines

Viewpoints
07:44 The One Big Beautiful Bill Act—Implications for Rural Health Care
07:51 Rural Hospitals Deserve More Than Patchwork Policies
08:05 Federal Funding Conditions Threaten Gender-Affirming Care Access and Physician Autonomy

Opinion
08:22 Women’s Health Is Everywhere—Introducing JAMA+ Women’s Health
08:57 Video: Introducing JAMA+ Women’s Health

JAMA+AI
09:37 The Promise and Challenge of AI for Women’s Health

Clinical Reviews and Education
10:59 Transparent Reporting of Observational Studies Emulating a Target Trial—The TARGET Statement
11:20 Hypothyroidism
11:40 Podcast: Diagnosis and Management of Hypothyroidism
12:11 Methamphetamine Use Disorder
12:29 Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder
12:49 Related Editorial: Are Psychedelic Agents Ready for Prime Time as Stand-Alone Treatments?
12:59 What Is Paternal Perinatal Depression?

Medical News http://jamamedicalnews.com?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public

Videos Mentioned:
https://youtu.be/SystUP-bIMc

Podcasts Mentioned:
JAMA Editors Summary
https://youtu.be/2ysnEuERbCY

JAMA Clinical Reviews
https://youtu.be/WvBEgHQ-dUc

JAMA+ AI Conversations
https://youtu.be/TCAVjeLeOrI

Links to articles mentioned in this podcast can be found at https://jamanetwork.com/journals/jama/fullarticle/2838700?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public

Podcast was originally published on September 5, 2025.
https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2025.11985?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public

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