How do immune checkpoint inhibitors work?

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In this primer video, Dr. Benjamin Schlechter explains the basic mechanisms that the immune checkpoint inhibitor drugs use to fight cancer.

Key Points:
1. T cells are designed to self-regulate their own activity
2. CLA-4 receptors dampen T-cell amplification (early)
3. PD1 receptors help to terminate T cell activation (late)
4. CTLA-4 and PD1 inhibitors prevent blunting of the immune system, allowing it to attack the cancer (and other cells too!)

Interested in learning more about checkpoint inhibitors and immune related adverse events (irAEs)?:
1. Explore our irAEs YouTube playlist: https://www.youtube.com/playlist?list=PLD6maWB-VZPBUsWcMTBoKQ73qMRcrozdh
2. Check out the full podcast episode at our website: https://www.coreimpodcast.com

#oncology, #immunotherapy, #checkpointinhibitors, #IRAEs, #internalmedicine, #medicaleducation,#residency, #CoreIM, #IMcore

Original interview by Shreya P. Trivedi MD and Anu Gupta MD.
Video content and editing by Chloe Gordon MD and Alice Kennedy MD.
Category
Oncology
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