Mechanisms of resistance to checkpoint inhibitors in head & neck cancer

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Amanda Psyrri, MD, PhD, FACP, National Kapodistrian University of Athens, Athens, Greece, discusses the limitations of immune checkpoint inhibition in recurrent metastatic head and neck squamous cell carcinoma. Different patterns of resistance to immune checkpoint inhibition include primary intrinsic resistance, adaptive resistance, clonal resistance, and acquired resistance. Therapeutic strategies to overcome resistance should focus on converting a cold tumor into an inflamed phenotype and increasing T-cell function and infiltration. This interview took place at 2025 European Society for Medical Oncology (ESMO) Immuno-Oncology Congress in London, UK.

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Oncology
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