Phase II trial of nivolumab and axitinib in mucosal melanoma

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Sarah Lochrin, MBBCh, Memorial Sloan Kettering Cancer Center, New York, NY, discusses a Phase II trial (NCT03602547) of nivolumab plus axitinib in patients with unresectable or advanced mucosal melanoma. The combination showed meaningful clinical activity and manageable safety, including in a non-Chinese population. For those progressing on doublet therapy, the addition of either ipilimumab or stereotactic body radiotherapy (SBRT) was evaluated in a pilot setting and appeared tolerable. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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