Redefining Urothelial Cancer Care: EV-Pembro, De-Escalation, and Future Strategies

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A virtual roundtable, hosted by Dr. Petros Grivas of Fred Hutchinson Cancer Center, contextualized the latest bladder cancer research updates and trials of relevancy to come out of the 2025 American Society of Clinical Oncology Genitourinary Cancers Symposium. Dr. Grivas was joined by Drs. Guru Sonpavde, Elizabeth Plimack, Christopher Wallis, Terence Friedlander, and Matthew Galsky.

In the first segment of the roundtable, the panel weighs the impact of long-term survival data from the EV-302 trial, with significant improvements in overall survival and outcomes across various patient subgroups. The conversation also touches on potential strategies to de-escalate treatment, including a pilot trial exploring induction and maintenance therapy to reduce long-term toxicities, and the role of ctDNA in clinical decision-making.
Category
Urology
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