Top 10 Myeloma Breakthroughs from ASCO & EHA: Frontline Therapy, Early & Late Relapse, CAR T Insight

Interested in the latest breakthroughs presented at ASCO and EHA this year? Dr. Joseph Mikhael, IMF Chief Medical Officer, condenses the top 10 multiple myeloma research updates across frontline therapy for newly diagnosed patients, early relapse (1–3 prior therapies), and late relapse (4+ prior therapies).

Learn how frontline quadruplets, MRD‑guided strategies, belantamab’s return, subcutaneous isatuximab, bispecifics in early relapse, record‑setting CAR T-cell therapies, and trispecific therapies are improving patients’ lives.

Topics Covered in this Video:
0:00 – Introduction
0:42 – PERSEUS trial: quadruplet + transplant → MRD‑negativity
1:45 – MIDAS trial: MRD‑guided transplant decisions
2:30 – GMMG‑CONCEPT: improved outcomes in high‑risk patients
3:08 – DREAMM‑7/8: belantamab triplets & relapse remissions
3:45 – SC isatuximab via on‑body injector (OBI)
4:17 – Early relapse bispecifics entering frontline
4:39 – CARTITUDE‑1 five‑year CAR T outcomes (33% disease‑free)
5:30 – Trispecific antibodies: stronger, safer immune therapy
6:14 – Next‑gen CAR T (anito‑cel) and reduced neurotoxicity
6:46 – RedirecTT‑1: bispecific combo conquers extramedullary MM
7:32 – Summary: from quadruplets to potential cures

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Improving Lives | Finding the Cure

Founded in 1990, the International Myeloma Foundation (IMF) is the first and largest organization focusing specifically on multiple myeloma. The IMF’s reach extends to more than 525,000 members in 140 countries worldwide. The IMF is dedicated to improving the quality of lives of myeloma patients while working toward prevention and a cure through our four founding principles: Research, Education, Support, and Advocacy.

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