"33% of Late Relapse Myeloma Patients Disease-Free at 5 Years?” | ASCO & EHA Breakthroughs 2025

Could a one-time CAR T-cell treatment keep late relapse multiple myeloma away for 5 years? In this update from ASCO and EHA 2025, Dr. Joseph Mikhael, Chief Medical Officer of the International Myeloma Foundation, shares the CARTITUDE-1 trial results and other late relapse breakthroughs that could change the future of myeloma care.

Whether you’re a patient, care partner, or healthcare professional, this deep dive covers four game-changing studies — from next-gen CAR-T designs to trispecific antibodies and combination therapies tackling hard-to-treat extra medullary disease.

Topics Covered:
0:00 - Introduction
1:06 - Why late relapse multiple myeloma is so challenging
1:37 - CARTITUDE-1: 33% disease-free at 5 years
3:20 - Trispecific antibodies: BCMA+CD38 and BCMA+GPRC5D targeting
4:16 - How trispecifics may improve safety and dosing frequency
5:21 - Anito-cel CAR-T: New design with fewer neurological side effects
6:38 - RedirecTT-1 Trial: Doubling response rates in extramedullary disease
8:15 - Takeaways for the future of late relapse myeloma treatment

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Founded in 1990, the International Myeloma Foundation (IMF) is the first and largest organization focusing specifically on multiple myeloma. The IMF’s reach extends to more than 525,000 members in 140 countries worldwide. The IMF is dedicated to improving the quality of lives of myeloma patients while working toward prevention and a cure through our four founding principles: Research, Education, Support, and Advocacy.

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