7. Anti anginal Drugs: Ivabradine & Fasudil: CVS Pharmacology

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Anti anginal Drugs: Ivabradine & Fasudil: CVS Pharmacology
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Ivabradine and Fasudil are unique anti-anginal drugs that provide symptomatic relief in ischemic heart disease through distinct mechanisms, making them valuable alternatives to traditional agents like nitrates, beta-blockers, and calcium channel blockers ????????. Ivabradine, a selective If (funny current) channel inhibitor, acts on the sinoatrial (SA) node, reducing heart rate (negative chronotropy) without affecting myocardial contractility or blood pressure, thus lowering oxygen demand while preserving cardiac output ????⚡.

This makes it especially useful in chronic stable angina and heart failure patients who cannot tolerate beta-blockers due to hypotension or bradycardia ⏳????. It is contraindicated in severe bradycardia, acute decompensated heart failure, and pregnancy ⚠️????.

Fasudil, on the other hand, is a Rho-kinase inhibitor that works by inhibiting vascular smooth muscle contraction, promoting vasodilation, and preventing coronary artery spasm, making it highly effective in vasospastic (Prinzmetal’s) angina ????????.
Additionally, Fasudil has neuroprotective effects and is being explored for conditions like stroke, pulmonary hypertension, and Alzheimer's disease ????????. Side effects of Ivabradine include visual disturbances (phosphenes), bradycardia, and atrial fibrillation, while Fasudil may cause hypotension and dizziness ????????.

Unlike nitrates, both Ivabradine and Fasudil do not cause tolerance, making them suitable for long-term angina management ????????. These drugs are often used as adjuncts alongside traditional therapies, providing better symptom control and improving exercise tolerance in chronic stable and vasospastic angina ????❤️. #Ivabradine #Fasudil

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