ESC 25: NEWTON-CABG CardioLink-5: Evolocumab and Saphenous Vein Graft Patency

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ESC Congress 2025 - NEWTON-CABG finds evolocumab with regular statin therapy did not improve vein graft patency after coronary artery bypass graft (CABG) surgery in the short-term.

Dr Subodh Verma and Dr Lawrence Leiter (University of Toronto, Toronto, CA) join us to discuss findings from NEWTON-CABG CardioLink-5 (NCT03900026). The investigator-initiated multicenter, randomised, placebo-controlled study aimed to investigate the effect of evolocumab on saphenous vein graft patency within 21 d coronary artery bypass graft (CABG) surgery. Before randomisation to either evolocumab or placebo, post-operative patients will be on moderate or high intensity statin therapy.

Findings showed that over 2 years, evolocumab produced a neutral result on vein graft patency after CABG surgery, However, evolocumab was found to lower LDL cholesterol by 60%.

Interview Questions:
What is the reasoning behind the NEWTON-CABG CardioLink-5 study?
What was the study design and patient population?
What were the key findings?
How should these findings impact clinical practice?
What further research is needed in this area?
Recorded on-site at ESC Congress 2025, Madrid.

Editors: Jordan Rance, Yazmin Sadik.
Videographers: Mike Knight, Dan Brent, Oliver Miles, Tom Green, David-Ben-Harosh.

Support: This is an independent interview produced by Radcliffe Cardiology.

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Categoria
Cardiology
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