Fat’s Stress Signal May Help Protect Heart

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Published Jun 16, 2025

A new study by UT Southwestern scientists has uncovered a surprising heart-protective mechanism linked to obesity. Researchers found that dysfunctional fat cells release mitochondrial fragments that act as a stress signal to the heart, prompting it to boost protective antioxidants. This discovery may explain the “obesity paradox,” where obese people show better short-term heart outcomes. The findings, observed in both mice and human tissues, could lead to therapies that protect against cardiac damage, even in non-obese individuals.

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