Expert Cancer Panel: Extensive stage SCLC w/ SVC syndrome and brain metastases

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Published
Recorded on 2/27/2021

75-year-old male with extensive stage small cell lung cancer with SVC syndrome and brain metastases

Summary:
- First line chemotherapy for small cell lung cancer consists of cisplatin-etoposide or carboplatin-etoposide, with or without atezolizumab/durvalumab
- Second line therapy consists of irinotecan/topotecan with platinum-based chemotherapy or nivolumab and ipilimumab
- Aggressive radiotherapy is indicated in the setting of SVC syndrome or developing SVC syndrome and in the setting of brain metastases
- Immunotherapy for small cell lung cancer remains experimental but RCT data are promising


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Category
Oncology
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