Expert Cancer Panel: Stage IV LUL adenosquamous; ALK neg, PD-L1 greater than 1%

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Published
Recorded on 2/27/2021

91-year-old Pakistani male with no smoking history, now diagnosed with stage IV adenosquamous of left upper lobe with bone metastasis. Molecular studies are negative for ALK alteration, PD-L1 greater than 1%, but there was insufficient tissue for additional studies

Summary:
- Cell-free DNA (liquid biopsy) is recommended for next generation sequencing
- If results show EGFR mutation, recommend initiation of osimertinib.
If actionable mutation is found in liquid biopsy, there is no need to confirm with tissue biopsy.


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Category
Oncology
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